4.5 · 13 reviewsRated 4.5 out of 5 from 13 reviews

Night Nutrient

Night crème · PM · 60 ml / 2 fl oz

This advanced cream promotes cellular repair mechanism (Genesis Factor®) in a unique approach to anti-aging, while providing potent hydration, and patented peptides for radiance and smoothness.

$110.00

Surgeon-developedGenesis Factor®Paraben-freeCruelty-free

Benefits
  • Ferulic acid stabilizes powerful vitamins like C and E, helping your skin fully absorb them for visible, lasting results
  • Visible anti-aging benefits, such as the improvement of fine lines and wrinkles, firmness, and brightening skin’s complexion
  • Enhances skin elasticity and promotes stronger, fresher collagen
  • Contains patented peptides and unique growth factor stimulants
  • Restores hydration and nutrients to improve the look of skin firmness
Key ingredients
Genesis Factor®
Iridesse’s signature complex — a proprietary blend of growth factors and cellular messengers that reprogram the skin’s overnight repair response, accelerating collagen and elastin renewal while you sleep.
Ferulic Acid
A potent antioxidant that enhances the activity of vitamins C and E, fighting oxidative stress and helping refine skin tone and firmness overnight.
Thioctic Acid (Alpha-Lipoic Acid)
A powerful universal antioxidant that boosts cellular metabolism, reduces inflammation, and visibly improves skin clarity and smoothness.
Azulene
Derived from chamomile, this blue-hued oil calms irritated skin and reduces redness — ideal for overnight soothing and rebalancing.
Jojoba & Shea Butter
Natural emollients that restore lipid balance and support the skin barrier with deep, non-comedogenic hydration.
Colloidal Oatmeal
A therapeutic, anti-inflammatory active that supports sensitive and compromised skin while encouraging recovery.
Patented Peptides
Clinically proven to stimulate fibroblast activity and promote high-performance collagen production for visibly firmer, smoother skin by morning.
How to use

Once a day, after cleansing, massage a thin, even layer onto the entire face, neck, and chest while avoiding eye area.

Skin types
Skin types
Dry, Normal, Sensitive, Post procedure
Skin condition
Dehydrated, Aging
Full ingredients

Water (Aqua), Ethyl Macadamiate, Lecithin, Glycerin, Simmondsia Chinensis (Jojoba) Seed Oil, Glycine Soja (Soybean) Oil, Potassium Cetyl Phosphate, Stearyl Alcohol, Sorbitan Stearate, Butyrospermum Parkii (Shea) Butter, Panthenine Hydrate, Thioctic Acid, Ferulic Acid, Plant Sterol Esters, Corn Syrup Solids, Sodium Caseinate, Dipotassium Phosphate, Distilled Monoglycerides, Silicon Dioxide, Ascorbyl Palmitate, Tocopherol, Aloe Barbadensis Leaf Juice, Colloidal Oatmeal, Allantoin, Fucus Vesiculosus Extract, Bisabolol, Lysolecithin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Carbomer, Azulene, 1,2-Hexanediol, Caprylyl Glycol, Tromethamine.

Complete the regimen
Day BrillianceCompletes the morning ritual · $100.00
The ritual

Best suited for

Skin types
Dry, Normal, Sensitive, Post procedure
Skin condition
Dehydrated, Aging
How to use
Once a day, after cleansing, massage a thin, even layer onto the entire face, neck, and chest while avoiding eye area.
Clinical record · Night Nutrient

Before & after

All results
Night Nutrient, beforeBefore
Night Nutrient, afterAfter
Night NutrientAfter 6 weeks · © Ruth L. Hillelson, MD, FACS
Day Brilliance, beforeBefore
Day Brilliance, afterAfter
Day Brilliance© Ruth L. Hillelson, MD, FACS
Eye Love It®, beforeBefore
Eye Love It®, afterAfter
Eye Love It®© Ruth L. Hillelson, MD, FACS
Kiss Lip Treatment, beforeBefore
Kiss Lip Treatment, afterAfter
Kiss Lip Treatment© Ruth L. Hillelson, MD, FACS
ME Body Silk Restoration, beforeBefore
ME Body Silk Restoration, afterAfter
ME Body Silk Restoration© Ruth L. Hillelson, MD, FACS
24%
Average increase in new collagen production within three weeks, measured by See-Through Technology imaging.
17%
Reduction in skin laxity, confirmed by elasticity laser testing.
27%
Increase in cheek elasticity after three weeks of twice-daily use.

In-house study: participants applied Iridesse® Day and Night formulations twice daily to one side of the face and forearm; the untreated side served as the control. Individual results vary.

The signature complex

Genesis Factor®

A proprietary blend of active ingredients designed to enhance skin repair and the natural growth of collagen and elastin, developed by plastic surgeon Ruth L. Hillelson over more than five years of research.

  • Repair & growthGenesis Factor®
  • Hydration & penetrationPatented peptides
  • Antioxidant amplifierFerulic acid
Explore the science
“Some things I keep with me always. Thank you Dr. Ruth Hillelson for introducing me to Iridesse skin care. I love it! It gets my skin polished up and ready for my next book tour.”

Patricia Cornwell · Author

In their words

Customer reviews

Customer Reviews

Based on 13 reviews
85%
(11)
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8%
(1)
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M
Myrtle Whitlock

Love it absorbs into skin so quickly and feels great.

M
Morgan Ledford

Sergio is the best! Night nutrient is my holy grail!

L
Leanne Mello Harkins

So far has made my face break out. Would like to return and get a credit or something, how do I do that??

J
Joan Walker

I started using the Iridesse products in my forties or fifties and am still using them at 87 years of age. Receive many compliments about my skin. Sergio is a jewel to work with.

C
Cindy Willis

I love the way this product feels on my skin. Lightweight, but does a great job of keeping my skin looking nice.